Book Hotels in Southwest Illinois, IL
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Top Southwest Illinois hotels
Drury Plaza Hotel Mt. Vernon
145 North 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $125 total per night from Jul 12 to Jul 13
$125 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
"Staff was very pleasant, our room was very nice and entire hotel was clean, shiny and classy!"
Reviewed on Jun 11, 2026
Drury Inn & Suites St. Louis O'Fallon, IL
1118 Central Park Drive O'Fallon IL
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $123 total per night from Jul 5 to Jul 6
$123 total
Jul 5 - Jul 6
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Great one-night stay. Room was quiet, bed was comfortable, and"free" food was good. Would recommend!"
Reviewed on Jun 8, 2026
The Principal Hotel
310 S Main St Columbia IL
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $121 total per night from Jun 14 to Jun 15
$121 total
Jun 14 - Jun 15
Total with taxes and fees
A restaurant and a gym are featured at this hotel. Free self parking, a coffee shop, and dry cleaning are also offered.
"Cute hotel in a former school. Looks brand new. Bed was perfect with full size pillows. Everything was very clean. A/C was turned down too low when we arrived. Room was freezing! Room had extra pilliws and blankets in the closet! It’s the little things that make a stay special"
Reviewed on Jun 8, 2026
Drury Inn & Suites Marion
2706 W DeYoung St Marion IL
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $115 total per night from Jun 28 to Jun 29
$115 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Great stay. Staff and property was excellent"
Reviewed on Jun 11, 2026
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $112 total per night from Jun 21 to Jun 22
$112 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"It was a simple stay, I didn’t spend much time at the hotel but they were quick with no issues. I might have left my white button up in the closet. But overall everything was fine."
Reviewed on Jun 9, 2026
Comfort Suites Mount Vernon
404 South 44th Street Mount Vernon IL
Fully refundable
$113 nightly
The price is $127 total per night from Jun 14 to Jun 15
$127 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Very nice hotel, breakfast was good, staff was friendly and very easy to get to off the freeway"
Reviewed on Jun 9, 2026
Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Dr East St. Louis IL
Fully refundable
$83 nightly
The price is $94 total per night from Jul 1 to Jul 2
$94 total
Jul 1 - Jul 2
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"We booked this hotel as out of town guests visiting St. Louis. Had no idea where we were staying. #1 it's in the ghetto. Bad roads literally and physically. #2 smells like pot. People was smoking pot and cigarettes just outside the front door. #3 We were charged a $100 incidental fee which still ..."
Reviewed on Jun 9, 2026
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $65 total per night from Jun 28 to Jun 29
$65 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
"they have roaches in every room, i was switch 5 times to different rooms even different floors. they have bed bugs my daughters were bit up all over even on their faces, i complained to the staff with no help they can hardly understand you, housekeeping is extremely rude even when they’re at fault, ..."
Reviewed on Jun 10, 2026
Welcome Suites
148 Regency Park O'Fallon IL
Fully refundableReserve now, pay when you stay
$46 nightly
The price is $53 total per night from Jun 14 to Jun 15
$53 total
Jun 14 - Jun 15
Total with taxes and fees
A gym, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. A picnic area and barbecue grills are also ...
"1. I always do the book now and pay later so I know what I’m paying for when I get to the hotel 2. I called the hotel to make sure me arriving early the next morning was ok and they said yes and for some reason they checked me in and charged my card. 3. I wasn’t made aware of that til I went to cancel ..."
Reviewed on Jun 8, 2026
Don't see what you're looking for?
See all available properties in Southwest Illinois
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Southwest Illinois hotels
Motel 6 Caseyville, IL - Caseyville Il
2431 Old Country Inn Dr Caseyville IL
$56 nightly
The price is $63 total per night from Jun 14 to Jun 15
$63 total
Jun 14 - Jun 15
Total with taxes and fees
6.4/10 (1,003 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Southwest Illinois with star-rating
Check Southwest Illinois Hotels by Star Rating
4 Star Hotels
3 properties
Recent Southwest Illinois hotel reviews by fellow wanderers
Drury Inn & Suites Marion
5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Great stay. Staff and property was excellent"
A verified traveler stayed at Drury Inn & Suites Marion
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